منابع مشابه
Neural tube defects: prevalence, etiology and prevention.
Spina bifida and anencephaly, the common form of neural tube defects, affect approximately 300 000 newborns each year worldwide. The effectiveness of folic acid supplementation in preventing their occurrence or recurrence has been unambiguous since 1991. In general, the prevalence of these abnormalities has decreased in the past 20 to 30 years because of periconceptional folate supplementation,...
متن کاملThe National Birth Defects Prevention Study: how to communicate data.
The National Birth Defects Prevention Study is a population-based case-control study. The study has actively sought to identify children with any of 34 specified types of malformation. The mothers of affected and unaffected children have been interviewed with regard to demographic information, lifestyle factors, and exposures. A large number of published studies have appeared and continue to ap...
متن کاملEtiology and clinical presentation of birth defects: population based study
Objective To assess causation and clinical presentation of major birth defects.Design Population based case cohort.Setting Cases of birth defects in children born 2005-09 to resident women, ascertained through Utah's population based surveillance system. All records underwent clinical re-review.Participants 5504 cases among 270 878 births (prevalence 2.03%), excluding mild isolated conditions (...
متن کاملAntibacterial medication use during pregnancy and risk of birth defects: National Birth Defects Prevention Study.
OBJECTIVE To estimate the association between antibacterial medications and selected birth defects. DESIGN, SETTING, AND PARTICIPANTS Population-based, multisite, case-control study of women who had pregnancies affected by 1 of more than 30 eligible major birth defects identified via birth defect surveillance programs in 10 states (n = 13 155) and control women randomly selected from the same...
متن کاملSystems Biology and Birth Defects Prevention: Blockade of the Glucocorticoid Receptor Prevents Arsenic-Induced Birth Defects
BACKGROUND The biological mechanisms by which environmental metals are associated with birth defects are largely unknown. Systems biology-based approaches may help to identify key pathways that mediate metal-induced birth defects as well as potential targets for prevention. OBJECTIVES First, we applied a novel computational approach to identify a prioritized biological pathway that associates...
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ژورنال
عنوان ژورنال: Molecular Cytogenetics
سال: 2014
ISSN: 1755-8166
DOI: 10.1186/1755-8166-7-s1-i24